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By Gisbert Schneider, Sung-Sau So

A short historical past of drug layout awarded to clarify that there are models during this vital box and they swap particularly speedily. this is often due partially to the truth that the way in which new paradigm is accredited in a drug corporation frequently doesn't depend upon its clinical advantage by myself.

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71. Schneider G, Schuchhardt J, Wrede P. Peptide design in machina: Development of artificial mitochondrial protein precursor cleavage-sites by simulated molecular evolution. Biophys J 1995; 68:434-447. 72. Davis L. Adapting operator probabilities in genetic algorithms. In: Schaffer JD, ed. Proceedings of the Third International Conference on Genetic Algorithms and Their Applications. San Mateo: Morgan Kaufmann, 1989:61-69. 73. Bäck T, Hoffmeister F, Schwefel HP. A survey of evolution strategies.

The optimization task is to adjust the free variables of the system in such a way that the network computes the desired output values. 8 (here, N is the number of data points (“patterns”) in the training set): Eq. 8 This error function is a special case of a general error function called the Minkowski-R error (Eq. 9): Eq. 9 where yk is the actual network output, tk is the desired (target) output vector, x is the input vector, and w is the weight vector. The summation over k will be omitted if only a single output neuron is used.

Mathematics of Control, Signals, and Systems 1989; 2:303-314. 129. Cybenko G. Continuous valued neural networks with two hidden layers are sufficient. Technical Report, Department of Computer Science, Tufts University, Medford, MA, 1988. 130. Baum EB, Haussler D. What size net gives valid generalization? Neural Computation 1989; 1:151-160. 131. Widrow B, Hoff ME. Adaptive switching circuits. In: 1960 IRE WESCON Convention Record, Part 4. New York: IRE, 1960:96-104. 132. McInerny JM, Haines KG, Biafore S, Hecht-Nielsen R.

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