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Extra resources for Advances in Surgical Pathology: Endometrial Carcinoma
Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol. 2007;26:103–114, with permission. 18 In Table 3-2, this new system is shown, together with its functional categories and the clinical management. Briefly, endometrial intraepithelial neoplasia (EIN) is considered to be the histopathologic manifestation of a monoclonal preinvasive glandular proliferation, and its diagnosis requires the following three criteria: 1. , the area of glands, combining epithelium and luminal spaces, is greater than that of the stroma that contains them; the stroma represents Ͻ50% of the tissue).
Simple or complex hyperplastic papillary proliferation, papillary proliferation, or benign papillary change). In our practice, we use the term “complex hyperplastic papillary proliferation” for those cases displaying a complex architectural pattern. In addition, we include a comment in the report indicating that this process represents a form of complex endometrial hyperplasia with metaplastic changes. 3,5,9 28 Section II • Histopathology FIGURE 3-12: Simple hyperplastic papillary proliferation of the endometrium in an endometrial polyp.
Endometrial hyperplasia: a review. Obstet Gynecol Surv. 2004;59:368–378. 15. Rubatt JM, Slomovitz BM, Burke TW, et al. Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia. Gynecol Oncol. 2005;99:472–476. 16. Skov BG, Broholm H, Engel U, et al. Comparison of the reproducibility of the WHO classifications of 1975 and 1994 of endometrial hyperplasia. Int J Gynecol Pathol. 1997;16:33–37. 17. Kendell BS, Ronnett BM, Isacson C, et al.