By Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)
Antibody-drug conjugates (ADCs) characterize a promising healing procedure for melanoma sufferers through combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic efficiency of chemotherapeutic medications. In Antibody-Drug Conjugates, specialist researchers offer unique protocols for plenty of of the main ADC strategies worthwhile for operating within the box. those chapters and methodologies are aimed toward the major initiatives essential to determine an appropriate objective, accurately layout the mAb, the linker and the payload, in addition to to conjugate them in a reproducible and scalable style. Written within the hugely winning Methods in Molecular Biology™ structure, those targeted chapters comprise the type of sensible implementation recommendation that promises caliber results.
Authoritative and well timed, Antibody-Drug Conjugates goals to extra force ADC improvement and therefore support towards bettering melanoma remedies of the future.
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Additional resources for Antibody-Drug Conjugates
McDonagh CF, Turcott E, Westendorf L et al (2006) Engineered antibody–drug conjugates with defined sites and stoichiometries of drug attachment. Protein Eng Design Select PEDS 19:299–307 118. Zhao RY, Wilhelm SD, Audette C et al (2011) Synthesis and evaluation of hydrophilic linkers for antibody–maytansinoid conjugates. J Med Chem 54:3606–3623 119. Moldenhauer G, Salnikov AV, L€ uttgau AV et al (2012) Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma.
Antibody–Drug Conjugate Target Selection: Critical Factors 5 39 Conclusions There is little doubt that weaving together the necessary components of an ADC requires optimal execution with respect to all of the components of the agent—antibody, linker, and drug. But it also requires a target that must meet equally stringent criteria, and the target is subject to few if any manipulations by the drug developer. Based on the criteria outlined above, it is likely that there are a relatively small number of tumor targets that would be optimal for ADC targeting.
In link with target expression features, progress of future ADC will require the capacity to better define the patient population which will benefit from the treatment. The development of improved companion diagnostics for the evaluation of target expression level and distribution in human tumor biopsies will be a critical asset. On top of the right target choice, developing and optimizing cytotoxics and linkers to improve efficacy and safety profile is mandatory but remains very complex and therefore challenging.