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Newman DJ. Cragg GM, Snader KM. Natural products as sourcesof new drugs over the period 1981-2002. J Nat prod 2003 ; 66:1022-1037. 4. Demain AL. Small bugs. big business : the economic power of the microbe . Biorechnol Adv 2000; 18:499-514. 5. , Fang A. The natural functions of secondary metabolit es. Adv Biochem Eng Biotechnol 2000 ; 69:1-39. NaturalProducts in DrugDiscovery 25 6. Fim RD, Jones CG . The evolution of secondary metabolism-a unifying model. Mol Microb iol 2000 ; 37:989-994. 7. Koehn FE.

64. Wang]. Soisson SM. Young K et aI. Platensimycin is a selective Fab inhibitor with potent antibiotic properties. Nature 2006; 441:358-361. 65. Young K. ]ayasuriya H. Ondeyka]G et al. Discovery of FabH/FabFinhibitors from natural products. Antimicrob Agents Chemother 2006; 50:519-526. 66. Payne D]. GwynnMN. HolmesD] er al. Drugsfor bad bugs: confronting the challenges of antibacterial discovery. Nature Rev 2007; 6:29-40. 67. Haney SA. Alksne LE. Dunman PM et aI. Genomics in anti-infective drug discovery-getting to endgame.

Swifi D. Longman E et aI. An evaluation of fluorescence polarization and lifttimediscriminated polarization for high throughput screening of serine/threonine kinases, Anal Biochem 2002; 308:223-231. 42. Turek-Etienne TC. Small EC. Soh CS ee al. Evaluation of fluorescent compound interference in 4 fluorescence polarization assays: 2 kinases, 1 protease and 1 phosphatase, ] Biomol Screen 2003; 8:176-184. 43. Cummins LL. Shuo Chen. Multitargetaffinity/specificity screening of natural products: finding and characterizing high-affiniry ligands from complex mixtures by usinghigh-performance mass spectrometry, ] Nat Prod 2003; 66:1186-1190.

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