By Jean-Maurice Vergnaud, Iosif-Daniel Rosca
Writing for pharmacology researchers and practitioners in drugs or pharmacology, Vergnaud (materials and chemical engineering, U. de Saint-Etienne, France) and Rosca (polymer Chemistry and expertise, Polytechnic U., Bucharest, Romania) clarify mathematical modeling to correlate in-vitro and in-vivo controlled-release drug dosage kinds. They current equipment for calculating the profiles of plasma degrees received with controlled-release dosage kinds, and supply examples and case reviews to demonstrate the suggestions. The grasp curves they current use dimensionless numbers in repeated doses, both for the time or for the plasma drug focus, and so might be utilized to any drug with a linear pharmacokinetics.
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Pharmacokinetics and sputum penetration of ciprofloxacin in patients with cystic fibrosis, Antimicrob. , Oct. 1986, 614, 1986. 2). AUC Area under the curve expressing the drug concentration vs. time. AUC0−− t Area under the curve from the time at which the dose is taken up to time t. C Free drug concentration in the blood. Cmax Drug concentration at the peak in the blood as a fraction of C∞. C∞ C∞ Drug concentration if all the drug in the dosage form were instantaneously in the blood. GI(T) Gastrointestinal (tract).
2. 5 of the drug. 4 is as follows. 5 60 hours. 5 ). 1. 2 for the subsequent doses delivered in succession (with the number n) and for various values of the interval of time T, expressed in terms of the half-life time through the dimensionless time θ . 3 CALCULATION OF THE AREA UNDER THE CURVE The area under the curve (AUC) is evaluated by using the relations that follow. 17) It is of interest to predict by calculation the value of the AUC associated with the system of n injections, when the half-life time of the drug is known, for various values of the interval of time T of the successive injections.
5 = 2 h. 3. 33 h. 10, curve 3, resulting from the fact that the subsequent dose is taken before the peak of the preceding one has been reached. , q, from 1 to 2) is responsible for two facts: • The steady state is attained after the same time. 5 for cimetidine. v. 1). v. shows that, with these two systems of drug administration, multidoses lead to the same increase in the maximum and minimum concentrations. , without considering the decrease resulting from the metabolic reaction in the liver due to the ﬁrst-pass hepatic.