By Leslie G. Dodd MD, Marilyn M. Bui MD PhD
This is an abundantly illustrated source for analysis of bone and tender tissue lesionsóa specific problem as a result of their rarity and complexity. as well as conscientiously chosen histologic pictures, this distinct atlas complements average visible info with illustrations of imaging findings, cytology, and molecular and cytogenetic info. This bright pictorial survey is prepared in a pattern-oriented procedure in accordance with the particular operating strategy utilized in day-by-day practice.
The authors are professional educators in surgical and cytopathology and skilled diagnosticians within the complexities of sentimental tissue and bone pathology. This richly illustrated and concise reference may be a realistic and indispensible software for normal pathologists and pathologists in education, who're required to diagnose bone and delicate tissue pathologies. it's also a very good source for physicians looking a brief survey of sarcoma.
- Offers a realistic, pattern-oriented diagnostic process that mirrors the operating approach utilized in day-by-day practice
- Augments histologic images with illustrations of imaging findings, cytology, and molecular and cytogenetic information
- Authored through famous specialist diagnosticians and academics within the field
Read or Download Atlas of Soft Tissue and Bone Pathology: With Histologic, Cytologic, and Radiologic Correlations PDF
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Extra resources for Atlas of Soft Tissue and Bone Pathology: With Histologic, Cytologic, and Radiologic Correlations
Thus far, the presence of this molecular signature has not been widely exploited. This is probably because the lesion most likely to be confused with lipoblastoma is myxoid liposarcoma. The latter is a neoplasm of adults and can be conﬁrmed with a ﬂuorescence in situ hybridization (FISH) for a DDIT3 gene rearrangement. As such, absence of this rearrangement can be very helpful in eliminating myxoid liposarcoma from the differential diagnosis. CYTOLOGIC FINDINGS Cytologic descriptions and illustrations of lipoblastoma are very rare.
8). Other x-ray ﬁndings, which help form the differential diagnosis or suggest speciﬁc histopathology, include pattern of tumor growth within a bone, peripheral (cortical) versus central (medullary) location, and reaction of host bone to the tumor (ie, sclerotic rim). Finally, integrating all available information on the ﬁlms with relevant clinical information can help further narrow a differential diagnosis and, in some cases, predict histopathology. For example, a young male with a thigh mass presenting with a dense, sclerotic distal femoral lesion with spiculated periosteal reaction would be consistent with osteoblastic osteosarcoma.
12). The nuclear atypia can be variable in appearance and may manifest as hyperchromasia or increased nuclear size and shape. Floret cells can occasionally be identiﬁed in aspirates of ■ 47 ALT/WDL, but are not speciﬁc for this entity. They are a frequent ﬁnding in the spindle cell/pleomorphic variant of lipoma as well. The best method to differentiate a benign lipoma from an ALT/WDL is to use ancillary techniques. Both FISH for MDM2 ampliﬁcation and immunohistochemical staining for the associated protein are available commercially.