By Karl Schügerl
This quantity covers tracking of the biotechnological technique with refined analytical thoughts, use of the ensuing info by way of mathematical versions, and computer-aided regulate for development of the productiveness of biotechnological techniques. The ebook involves 4 major elements: tools for research and biosensoring, measuring innovations, method versions and their automation and keep an eye on. using varied mobilephone varieties, recombinant microorganisms, and reactor stipulations are offered and all current innovations of tracking and optimizing phone progress and product formation are mentioned with reference to more suitable productiveness. themes incorporated are: tools and tools/ Biosensors/ Characterization of Bioreactors/ choice of telephone focus/ mobilephone versions/ Stirred Tank versions/ Tower Reactor versions/ method types/ keep watch over of Bioreactor platforms/ Automation/ regulate of Downstream Processing
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Additional resources for Biotechnology, 2nd Edition, Volume 4: Measuring, Modelling and Control
Computer Control in Fermentation, Dijon, France. , INGOLD,W. , 19-24. BUNGAY,H. , 111, CHEN,Y. S. (1981), Dissolved oxygen profiles in photosynthetic microbial slimes, BiotechnoL Bioeng. 23, 1893-1895. BUNGAY,H. , 111, HAROLD,D. , Jr. (1971), Simulation of oxygen transfer in microbial slimes, Biotechnol. Bioeng. 13, 569-579. BUNGAY,H. , III, WHALEN,W. , SANDERS, W. M. (1969), Microprobe techniques for determining diffusivities and respiration rates in microbial slime systems, Biotechnol. Bioeng.
E. (1978), Realtime estimation of aerobic batch fermentation biomass concentration by component balancing, AIChE J. 24, 138-146. 2 Methods and Instruments in Fermentation Gas Analysis E LMAR HEI N Z LE IRVING J. 08314bar L mol-' K - I ) respiratory quotient (-) relative statistical error (-) time (s) temperature (K, "C) velocity (m s-') volume (m3, L) biomass concentration (g L - I ) gas phase molar fraction ( - ) thickness (m) time constant (s) molar flux (=specific reaction rate) (mol kg-ls-') Subscripts and Superscripts E electrode G gas phase i index for component inert inert gas L liquid phase re1 relative X biomass 0 input into the reactor 1 output from the reactor * refers to gas-liquid equilibrium ' relative value ( - ) 29 30 2 Methods and Instruments in Fermentation Gas Analysis 1 Introduction gen and CO, production can be measured simultaneously by first measuring pressure change and subsequently absorbing CO, in an It is evident from Chapter 1 of this volume alkaline solution, then making a final pressure of “Biotechnology” that on-line fermentation measurement.
1985). Usually deoxygenation is accomplished with nitrogen so that the initial gas phase consists of nitrogen, which is gradually displaced and mixed with air. Under these conditions C, is not constant and the gas balance must be employed to calculate CGlversus t. Since CLl is measured with a membrane-covered oxygen electrode, the dynamics of the method of measurement cannot usually be neglected. Experimentally this is described approximately by a first order lag equation The relative influence of the three processes depends on the values of the constants rG= VG/G, l/KLa, and r E .