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By E.S.Grace

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Some of the light is absorbed by the tissue while a certain portion of the light is diffusely scattered and reflected back to the skin surface (after interacting with the tissue, or exciting vibrational modes of the analyte molecule in the tissue). The intensity of this diffuse reflectance is dependent on both the scattering coefficient and the absorption coefficient of the tissue. e. diffuse reflectance vs. distance) can be recorded. ” (Adapted from Heinemann et al [89]). The effects of light scattering and light absorption from the recorded light intensity can be differentiated by algorithms designed based on diffusion theory of light propagation in tissue [63].

The effects of light scattering and light absorption from the recorded light intensity can be differentiated by algorithms designed based on diffusion theory of light propagation in tissue [63]. A neural-network can be used to extract the optical properties from the reflectance data [91]. Examples of the measuring instruments include diode-array spectrometer with InGaAs detector [78], FTIR spectrometer with nitrogen-cooled InSb detectors [96], LED arrays with photodetector arrays [63], and He-Ne laser beam with CCD camera [97].

G. by pressing on the finger). It was reported that the glucose in arterialized whole blood correlated with glucose prediction by O-RNIRS [103]. Yamakoshi et al [105] used the concept of AC measurement in “Pulse glucometry” technique, where Near-IR transmittance spectra was taken during normal blood volume pulsations throughout the cardiac cycle. PLS calibration is used to predict the BG values. Their approach differs to “occlusion spectrometry” in that no pressure was applied to the tissue during measurement.

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