Download Cancer Chemotherapy by Alan C. Sartorelli (Eds.) PDF

By Alan C. Sartorelli (Eds.)

content material: improvement of [alpha]-(N)-heterocyclic carboxaldehyde thiosemicarbazones with scientific capability as antineoplastic brokers / Alan C. Sartorelli and Krishna C. Agrawal --
Adriamycin / David W. Henry --
Biochemical pharmacology of the anthracycline antibiotics / Nicholas R. Bachur --
power bioreductive alkylating brokers / Ai Jeng Lin, Lucille A. Cosby, and Alan C. Sartorelli --
A overview of stories at the mechanism of motion of nitrosoureas / Glynn P. Wheeler.

Show description

Read Online or Download Cancer Chemotherapy PDF

Similar oncology books

Melanoma - Biologically targeted Therapeutics (Current Clinical Oncology)

Ernest C. Borden, MD, has assembled a multidisciplinary staff of validated and rising leaders to element the medical difficulties and elements influencing the healing deployment of those biologicals. The individuals specialize in supplying the explanation and history for translating the various promising biologically distinct remedies through medical trials into potent new remedies.

The Royal Marsden Hospital Handbook of Wound Management In Cancer Care

The Royal Marsden health center instruction manual of Wound administration in melanoma Care bargains evidence-based assistance on wound administration in a realistic and simply obtainable structure. An creation to wound therapeutic and evaluation is by means of the administration of particular wound forms and an in depth bankruptcy on wound administration items.

Breast Disease: Management and Therapies

This moment quantity of the guide on breast illness offers a accomplished evaluate of its scientific administration and present treatments. It brings readers up to the mark with the newest guidance and healing regimens in breast melanoma and offers and in-depth account of present and new healing methods.

Additional resources for Cancer Chemotherapy

Sample text

A l t e r a t i o n of c e l l surface a r c h i t e c t u r e i s a new e f f e c t of adriamycin r e c e n t l y reported by Murphree et a l . (93). Using a new assay technique (94) they found that concanavalin A-induced a g g l u t i n a t i o n of S180 c e l l s was enhanced s e v e r a l f o l d f o l l o w i n g drug exposure. As the amount of l e c t i n bound was unchanged t h i s suggests that adriamycin a f f e c t s the c l u s t e r i n g of concanavalin A binding s i t e s . The p o s s i b i l i t y that adriamycin and daunomycin act by i n t e r ference with microtubule f u n c t i o n during m i t o s i s has been r a i s e d by the work of Dano (95,96).

In the f o l l o w i n g d i s c o u r s e the model w i l l be d i s c u s s e d i n terms of i t s a b i l i t y to r a t i o n a l i z e t e s t data among a n t h r a c y c l i n e d e r i v a t i v e s and analogs. Daunomycin and ^A^iamycin Dérivât The c a r b o n y l group at C-ÎT^oT^dajji^ selectively derivat i z e d by standard carbonyl reagents and, as would be expected, the amino group i s a l s o s e l e c t i v e l y attacked by a c y l a t i n g agents. For t h i s reason d e r i v a t i v e s on these f u n c t i o n a l groups r e c e i v e d e a r l y a t t e n t i o n i n s t r u c t u r e - a c t i v i t y s t u d i e s (51,98).

I t i s c l e a r that adriamycin and daunomycin have profound d e l e t e r i o u s e f f e c t s on n u c l e i c a c i d synthesis and t h i s property must be involved i n t h e i r mechanism of a c t i o n . However, not a l l DNA-related b i o l o g i c a l t h e s i s i n h i b i t i o n . Fo a n t i m i t o t i c e f f e c t s were evident i n c u l t u r e d mouse c e l l s at daunomycin l e v e l s much too low to a f f e c t n u c l e i c a c i d synthes i s (82). They a l s o demonstrated that the drug abruptly blocked m i t o s i s when given only a few minutes before prophase.

Download PDF sample

Rated 4.66 of 5 – based on 14 votes