Download Cancer Chemotherapy and Biotherapy: Principles and Practice by Dan Longo, Bruce A. Chabner PDF

By Dan Longo, Bruce A. Chabner

Updated to incorporate the latest medicinal drugs and people at present in improvement, Cancer Chemotherapy and Biotherapy, 5th Edition is a finished reference at the preclinical and scientific pharmacology of anticancer brokers. equipped through drug classification, the e-book presents the newest info on all medicinal drugs and organic agents—their mechanisms of motion, interactions with different brokers, toxicities, unintended effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of motion on the molecular and mobile degrees, through medical task and toxicity, either acute and behind schedule. The authors clarify the explanation to be used of gear in particular schedules and combos and provide guidance for dose adjustment particularly situations.

This edition's creation comprises well timed details on common ideas for drug utilization, the technology of drug discovery and improvement, fiscal and regulatory elements of melanoma drug improvement, and rules of pharmacokinetics. 8 new chapters were extra and greater than twenty were considerably revised.

A spouse site comprises the absolutely searchable textual content and a picture bank.

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Extra info for Cancer Chemotherapy and Biotherapy: Principles and Practice (Chabner, Cancer Chemotherapy and Biotherapy)

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Theoretic limitations of intracarotid infusions in brain tumor chemotherapy. Cancer Treat Rep 1977;61:519. 50. Eckman WW, Patlak CS, Fenstermacher JD. A critical evaluation of the principles governing the advantages of intraarterial infusions. J Pharmacokinet Biopharm 1974;2:257. 51. Collins JM. Pharmacokinetic rationale for intraarterial therapy. In: Howell SB, ed. Intra-arterial and intracavitary cancer chemotherapy. Boston: Martinus Nijhoff, 1985:1. 52. Speth PAJ, Kinsella TJ, Chang AE, et al.

For infectious diseases, the goal is prolonged maintenance of plasma concentration above a minimal inhibitory concentration or minimal bactericidal concentration but below a level toxic to the host. In anticancer chemotherapy, although the general goal of killing tumor cells is clearly defined, in most cases we are severely limited by an inability to select concentration-time parameters that separate antitumor effects from normal tissue toxicity. Much remains to be learned about the differences between normal and tumor tissues that can be exploited therapeutically.

Cancer Res 1986;46:1795. 24. Hande K, Combs G, Swingle R, et al. Effect of cimetidine and ranitidine on the metabolism and toxicity of hexamethylmelamine. Cancer Treat Rep 1986;70:1443. 25. Bjornsson TD, Huang AT, Roth P, et al. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. Clin Pharmacol Ther 1986;39:25. 26. Balis FM. Pharmacokinetic drug interactions of commonly used anticancer drugs. Clin Pharmacokinet 1986;11:223. 27. Jamis-Dow CA, Klecker RW, Katki AG, et al.

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